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Cell Culture Modelling

Testis Micro Early Diagnosis Kit

A diagnostic kit for preclinical research built on human-specific cell lines and microchip technology — a faster, more ethical alternative to animal testing.

Çalışma künyesi
  • DestekKOSGEB funded project
  • Status 2023 – Ongoing
  • CategoryCell Culture Modelling
Testis Micro Early Diagnosis Kit — laboratory image

Testis Micro is an early-diagnosis kit that brings together human-focused microchip technology and test-specific cell lines for preclinical research. A testis-specific microchip hosts 3D cell culture that mimics the physiological environment, and candidate drugs and chemical substances are evaluated in that setting.

The model rests on a cell culture model built with a Lab-on-a-Chip approach to study the dynamics of the blood–testis barrier within the testicular microenvironment. It provides a basis for permeability studies in reproductive biology and pharmacology.

Nasıl çalışıyor?

  1. Human-specific cell lines

    Human-specific cell lines derived from testicular tissue

  2. Microchip platform

    Physiological environment mimicked by 3D cell culture on a testis-specific microchip

  3. Drug / compound application

    Candidate drugs or chemical compounds applied on the microchip

  4. Real-time analysis

    Multi-parameter analysis and high-content data acquisition

More accurate, faster and more ethical results

An alternative to animal testing, with results closer to humans

Kullanılan hücre serileri

  • Sertoli Cells

    Modelling supportive functions and barrier structure

  • Leydig Cells

    Assessing hormone production and endocrine responses

  • Spermatogonial Stem Cells

    Studying developmental processes and reproductive function

  • Peritubular Myoid Cells

    Testicular microarchitecture and cell-to-cell interaction studies

Yaklaşımın kazanımları

  • High predictive accuracy through human-specific cells
  • Reduces animal use — ethical and sustainable
  • Cost advantage through smaller samples and less reagent
  • Real-time, multi-parameter analysis
  • Accelerates drug development
  • Contributes to personalised medicine

Methods applied in this study

Human-specific cell lines Microchip platform Real-time analysis Cell culture Lab-on-a-Chip Barrier integrity monitoring Immunofluorescence staining
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